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投稿时间：2018-08-02 网络发布日期：2019-03-22
投稿时间：2018-08-02 网络发布日期：2019-03-22
中文摘要: 目的 研究初发结直肠癌患者肿瘤TNM分期、部位以及性别与空腹血脂水平的相关性。方法 回顾性分析2015年1月至2017年12月住院经病理初次诊断为结直肠癌的患者64例,同时筛选健康体检者41例作为对照组,观察两组空腹甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平变化规律,分析其与结直肠癌TNM分期、发生部位以及性别的相关性。结果 与对照组相比,结直肠癌组患者空腹血清TG水平明显高于对照组［(1.94±0.88)mmol/L vs (1.45±0.67)mmol/L,P=0.003］,HDL-C明显低于对照组［(0.76±1.34)mmol/L vs (1.41±0.53)mmol/L,P=0.003］,且结直肠癌患者的TG水平随TNM分期的升高而上升(P<0.01);左半结肠+直肠癌患者血清TG高于右半结肠癌患者,HDL-C低于右半结肠癌患者(P<0.05),男性结直肠癌患者血清中TG、HDL-C水平高于女性结直肠癌患者(P<0.05)。结论 空腹血TG升高,HDL-C降低可能是初发结直肠癌脂质代谢性紊乱的表现,初发结直肠癌患者的空腹TG水平升高越明显,TNM分期高、肿瘤浸润程度深的可能性越大。
Abstract:Objective To study the correlation between TNM staging, site, gender and fasting blood lipid level in patients with primary colorectal cancer. Methods Sixty-four patients with colorectal cancer initially diagnosed by pathology from January 2015 to December 2017 (case group) and 41 healthy people (control group)were selected as study subjects.The changes in fasting triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL-C), low density lipoprotein (LDL-C) levels were observed, and their associations with TNM staging, location of colorectal cancer and patients′ sex were analyzed. Results Compared with control group, TG level significantly increased (P＜0.01), HDL-C decreased significantly (P<0.01)in case group. And the level of TG in patients with colorectal cancer increased with the increase of TNM stage (P<0.01). In patients with colorectal cancer located in the left-sided colon cancer and rectum, serum TG level was higher than that in the right-sided colon cancer, and HDL-C level was lower than that in the right-sided colon cancer (P<0.05).In male patients, serum levels of TG and HDL-C were statistically higher than those in female patients with colorectal cancer (P<0.05). Conclusion The increase of TG and the decrease of HDL-C may be the manifestation of lipid metabolic disorder in patients with primary colorectal cancer.The higher the level of fasting TG in primary colorectal cancer patients, the greater the likelihood of high TNM stage (the deeper the tumor infiltration).
文章编号： 中图分类号：R 735.3+5 文献标志码：B
基金项目:山东省自然科学基金联合专项（2015ZRB14534）
| Author Name | Affiliation |
| DING Xiao-rui, LIU Cheng-xia, JIA Xing-fang | Department of Gastroenterology, Binzhou Medical University Hospital, Binzhou, Shandong 256600, China |
引用文本：
丁晓蕊,刘成霞,贾兴芳.初发结直肠癌TNM分期、生长部位以及性别与患者空腹血脂水平的相关性[J].中国临床研究,2019,32(3):364-366.
丁晓蕊,刘成霞,贾兴芳.初发结直肠癌TNM分期、生长部位以及性别与患者空腹血脂水平的相关性[J].中国临床研究,2019,32(3):364-366.