Abstract:Objective To investigate the time-of-flight (TOF) magnetic resonance angiography (MRA) combined with 3D-arterial spin labeling (3D-ASL) in cerebral artery stenosis and occlusion.? Methods The vascular morphology of TOF MRA in 42 patients with cerebral artery stenosis or occlusion was reviewed. Relative cerebral blood flow (rCBF) was measured and the diagnostic results of TOF MRA and 3D-ASL were compared.? Results The coincidence rate of TOF MRA and 3D-ASL in diagnosis of massive cerebral infarction was 100%. There were 39 patients (93%) had cerebral artery stenosis or occlusion with 3D-ASL perfusion abnormality and 3 patients (7%) without 3D-ASL perfusion abnormality.? Conclusion 3D-ASL could analyze cerebral blood flow perfusion information in patients with cerebral artery stenosis and occlusion quantitatively. The diagnostic accuracy of TOF MRA and 3D-ASL is consistent in patients with massive cerebral infarction. For some patients with superior cerebral artery stenosis and occlusion in TOF MRA, because of collateral circulation compensation, there may be no large area cerebral infarction and without perfusion abnormality in 3D-ASL. The combination of TOF MRA and 3D-ASL could provide more accurate assessment of cerebrovascular diseases and provide guidance for clinical treatment.