Abstract:Objective To observed the short- and long-term effect of modified cocktail therapy and manipulation under anesthesia (MUA) combined with rehabilitation exercise in the treatment of primary frozen shoulder (PFS). Method Retrospective analysis was carried out with modified cocktail therapy and release manipulation combined with rehabilitation exercise for PFS patients who received treatment from January 2014 to January 2016. The range of motion and shoulder pain and disability index (SPADI) before and after the treatment and cure rate were recorded and compared. Results A total of 120 PFS patients were included in the study. After 3 days and 1 month of treatment, the active flexion and uplift, abduction and uplift, adduction, extension, internal and external rotation of shoulder joint were significantly improved (all P<0.01), and these improvements at 1 month after the treatment were better than those at 3 days after the treatment (all P<0.01). Before the treatment, 3 d, 1 month and 1 year after the treatment, the SPADI was gradually reduced with the prolonged treatment time(67.87±19.24 vs 30.35±15.53 vs 15.63±7.32 vs 10.28±5.26, P<0.01). After 3 days, 1 month and 1 year of treatment, the cure rate increased gradually with the prolonged treatment time (66.7% vs 91.7% vs 99.2%, P<0.01). Conclusion In the treatment of primary frozen shoulder, modified cocktail therapy and manipulation combined with rehabilitation exercise could significantly relieve pain and improve shoulder function, and its curative effect of both short- and long-term is good.