Abstract:Objective To investigate the effect of concentrate growth factor (CGF) on immediate implant repair in patients with chronic periodontitis to provide reference for the clinical application of CGF in oral implanting. Methods A retrospective analysis was performed for the clinical data of 95 patients (101 teeth) with chronic periodontitis who received immediate implanting from December 2015 to August 2016. The patients were divided into observation group (48 cases, 52 sick teeth) and control group (47 cases, 49 sick teeth) according to the difference of material added in the implant-bone gap. Bio-Oss was added to the implant-bone gap for guiding bone regeneration in control group. CGF and Bio-Oss mixture was added to the implant-bone gap in observation group. The adverse reactions within 10 days after operation were recorded. Marginal bone absorption amounts were compared between two groups on the day of operation, 3 months and 6 months after the operation. The modified plaque index (mPLI) and modified sulcus bleeding index (mSBI) were compared between two groups at 3 months and 6 months after operation. Results The incidence of total adverse reaction in observation group was slightly lower than that in control group, but there was no significant difference (5.77% vs 16.33%, P>0.05). Compared with control group, marginal bone absorption amounts of the implants decreased in observation group on the day of operation [(0.30±0.09)mm vs (0.41±0.15)mm], 3 months[(0.41±0.18)mm vs(0.79±0.25)mm] and 6 months [(0.46±0.21)mm vs(1.19±0.22)mm] after the operation (all P<0.05). The mPLI of 3 months and 6 months after operation in observation group were significantly higher than those in control group(0.62±0.10 vs 0.45±0.08, 0.87±0.12 vs 0.65±0.09, all P<0.05). The MSBI of 3 months(0.70±0.11 vs 0.52±0.14)and 6 months after operation (0.95±0.14 vs 0.67±0.12) were also significantly higher in observation group than those in the control group (all P<0.05). Conclusion The combination adding CGF and Bio-Oss to the implant-bone gap for the immediate implant repair of chronic periodontitis patients has good clinical effect. However, it is still necessary to pay attention to regular reexamination and the guidance of oral hygiene to the patients.